Article
An A. thaliana mutant lacking all nine ATG8 isoforms provides genetic evidence for functional specialization of ATG8 in plants.
Journal of cell science - 1 Sept 2025
Del Chiaro Alessia, Grujic Nenad, Zhao Jierui, Papareddy Ranjith Kumar, Gao Peng, Ma Juncai, Lofke Christian, Bhattacharya Anuradha, Gruetzner Ramona, Bourguet Pierre, Berger Frédéric, Kang Byung-Ho, Marillonnet Sylvestre, Dagdas Yasin
Abstract excerpt
Autophagy sustains cellular health by recycling damaged or excess components through autophagosomes. Autophagy is mediated by conserved ATG proteins, among which the ubiquitin-like ATG8 proteins play a central role by linking cargo to the growing autophagosomes. Unlike most ATG proteins, the ATG8 gene family is significantly expanded in vascular plants, but its functional specialization remains poorly understood....
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