Article
tRNA processing in human mitochondrial disorders.
Molecular biology reports - 1 Jan 2000
Masucci J P, Schon E A
Abstract excerpt
Many human mitochondrial disorders are associated with mutations in tRNA genes or with deletions of regions containing tRNA genes, all of which may be suspected to play a role in recognition by RNase P. Here we describe the analysis of five such mutations. The results presented here demonstrate t...
Topics
- Animals
- Base Sequence
- DNA, Mitochondrial
- Endoribonucleases
- Humans
- Mammals
- Mitochondria
- Mitochondrial Myopathies
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Catalytic
- RNA, Transfer
- Ribonuclease P
- Sequence Deletion
- Transcription, Genetic