Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis.

Abstract excerpt

Evidence that HTR2A receptor gene may be subject to genomic imprinting prompted us to examine a collection of family trios for evidence of an association between the HTR2A T102C polymorphism and psychosis in schizophrenia or bipolar disorder. We also tested for the possibility of imprinting by employing quantitative RT-PCR to measure the relative expression of post-mortem brain mRNA for each allele in 45 subjects...

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