Heme-CO binding to tryptophan-containing calmodulin mutants.

Abstract excerpt

The binding of heme-CO to genetically engineered calmodulin containing a single tryptophan residue has been studied. A tryptophan residue was integrated at one of five positions: 26 or 62 of the N-terminal, 81 in the central helix, or 99 or 135 of the C-terminal. As for the wild type, the mutant calmodulins bind four molecules of heme-CO with an average affinity of 1 microM. (i) Homotropic effect. The quenching...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Cattle
• Share to Heme