Article
Mapping of a gene for Parkinson's disease to chromosome 4q21-q23.
Science (New York, N.Y.) - 15 Nov 1996
Polymeropoulos M H, Higgins J J, Golbe L I, Johnson W G, Ide S E, Di Iorio G, Sanges G, Stenroos E S, Pho L T, Schaffer A A, Lazzarini A M, Nussbaum R L, Duvoisin R C
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with...
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