Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Normal physiology and phenotypic characterization of beta-cell function in subjects at risk for non-insulin-dependent diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association - 1 Sept 1996

Porte D

Abstract excerpt

Major genes for NIDDM appear to be rare. Therefore, phenotypic characterization of the pathophysiological changes contributing to hyperglycaemia are assuming increasing importance. Assessment of beta-cell function has been hampered by two major confounding factors during functional testing: variable insulin sensitivity and plasma glucose levels. These and other methodological variables are discussed with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to C-Peptide
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Secretion

Share to Islets of Langerhans

Share to Phenotype

Share to Risk Factors

Source

Identifiers

PMID: 8894477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Normal physiology and phenotypic characterization of beta-cell function in subjects at risk for non-insulin-dependent diabetes mellitus.PMID 8894477Read ↗

Human Physiology of Genetic Defects Causing Beta-cell Dysfunction.Semantic proximity Read ↗

Toward an integrated phenotype in pre-NIDDM.Semantic proximity Read ↗

Different β-cell secretory phenotype in non-obese compared to obese early type 2 diabetes.Semantic proximity Read ↗

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.Semantic proximity Read ↗

Influence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell FunctionSemantic proximity Read ↗

Comprehensive validation of fasting- and oral glucose tolerance test-based indices of insulin secretion against gold-standard measuresSemantic proximity Read ↗

Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds.Semantic proximity Read ↗

Assessment of insulin sensitivity in glucokinase-deficient subjects.Semantic proximity Read ↗

Pathogenic mechanism of type 2 diabetes in Ghanaians--the importance of beta cell secretion, insulin sensitivity and glucose effectiveness.Semantic proximity Read ↗

Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.Semantic proximity Read ↗

The Prevalent Gly1057Asp Polymorphism in the Insulin Receptor Substrate-2 Gene Is Not Associated with Impaired Insulin SecretionSemantic proximity Read ↗

Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.