Article
Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes.
Diabetes care - 1 Jul 2003
Thamer Claus, Stumvoll Michael, Niess Andreas, Tschritter Otto, Haap Michael, Becker Regine, Shirkavand Fatemeh, Bachmann Oliver, Rett Kristian, Volk Annette, Häring Hans, Fritsche Andreas
Abstract excerpt
OBJECTIVE: Studies on insulin sensitivity and insulin secretion in subjects with a familial predisposition for type 2 diabetes mellitus (T2DM) traditionally produce inconsistent results. This may be due to small sample size, subject selection, matching procedures, and perhaps lack of a measure of physical fitness. RESEARCH DESIGN AND METHODS: In the present study, we specifically tested the hypothesis that a...
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