Article
A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.
European journal of oral sciences - 1 Dec 2009
Lu Xincheng, Rios Hector F, Jiang Baichun, Xing Lianping, Kadlcek Renata, Greenfield Edward M, Luo Guangbin, Feng Jian Q
Abstract excerpt
A new spontaneous mouse mutant (ntl) with autosomal-recessive osteopetrosis was characterized. These mice formed tartrate-resistant acid phosphate (TRAP)-positive osteoclasts but their osteoclasts had no ruffled border and did not resorb bone. These mice displayed no tooth eruption or tooth root formation. Adult mutant mice developed odontoma-like proliferations near the proximal ends of the incisors....
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