Article
p21ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1996
Lorenzo M, Valverde A M, Teruel T, Alvarez A, Benito M
Abstract excerpt
Transfection of primary rat fetal brown adipocytes with constructs of SV40 large T antigen, alone and together with lys12-mutated H-ras gene, gave permanent cell lines showing an immortalized or transformed phenotype, respectively, all of them selected by the expression of the uncoupling protein (UCP), a tissue-specific marker. Primary brown adipocytes and immortalized cell lines respond to insulin-like growth...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.