Article
The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study.
Circulation - 15 Oct 1996
Jukema J W, van Boven A J, Groenemeijer B, Zwinderman A H, Reiber J H, Bruschke A V, Henneman J A, Molhoek G P, Bruin T, Jansen H, Gagné E, Hayden M R, Kastelein J J
Abstract excerpt
BACKGROUND: Many patients suffering from premature coronary artery disease report a family history for such events. A mutation in a particular gene, which confers susceptibility for atherosclerosis, will be found more frequently in individuals suffering from coronary atherosclerosis than in the general population. We have recently reported the identification of an Asp9 Asn substitution in the lipoprotein lipase...
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