CONRAD: a method for identification of variable and conserved regions within proteins by scale-space filtering.

doi:10.1093/bioinformatics/12.3.197

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Article

CONRAD: a method for identification of variable and conserved regions within proteins by scale-space filtering.

Computer applications in the biosciences : CABIOS - 1 Jun 1996

Herrmann G, Schön A, Brack-Werner R, Werner T

Abstract excerpt

Advanced sequencing techniques allow rapid deduction of individual amino acid sequences of highly related proteins. Due to their quasi-species nature, viral genomes (e.g. HIV-1) represent one of the most common sources of related proteins. Another example of related proteins are immunoglobulins. Local differences in amino acid conservation are useful indicators of potential domain structures and immunological or...

Topics

Algorithms
Amino Acid Sequence
Conserved Sequence
Genetic Variation
HIV Envelope Protein gp120
Humans
Immunoglobulin Variable Region
Immunoglobulin lambda-Chains
Molecular Sequence Data
Proteins
Sequence Alignment
Sequence Homology, Amino Acid
Software

Source

Open in PubMed

Identifiers

PMID: 8872388
DOI: 10.1093/bioinformatics/12.3.197

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