Analysis of sequence variation among legume lectins. A ring of hypervariable residues forms the perimeter of the carbohydrate-binding site.

Abstract excerpt

Twelve plant lectins from the Papilionoideae subfamily were selected to represent a range of carbohydrate specificities, and their sequences were aligned. Two variability indices were applied to the aligned sequences and the results were analysed using the three-dimensional structures of concanavalin A and the pea lectin. The areas of greatest variability were located in the carbohydrate-binding site region,...

Topics

• Amino Acid Sequence
• Binding Sites
• Carbohydrate Metabolism
• Concanavalin A
• Fabaceae
• Genetic Variation
• Lectins
• Models, Molecular
• Molecular Sequence Data
• Plant Lectins
• Plants, Medicinal