Leber's hereditary optic neuropathy with the 11 778 mtDNA mutation and white matter disease resembling multiple sclerosis: clinical, MRI and MRS findings.

doi:10.1016/0022-510x(95)00287-c

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Article

Leber's hereditary optic neuropathy with the 11 778 mtDNA mutation and white matter disease resembling multiple sclerosis: clinical, MRI and MRS findings.

Journal of the neurological sciences - 1 Feb 1996

Jansen P H, van der Knaap M S, de Coo I F

Abstract excerpt

A mother and her son are reported who suffer from Leber's hereditary optic neuropathy (LHON) with the 11778 mtDNA mutation. In both subjects additional clinical and paraclinical evidence of a cerebral demyelinating disease was found. This combination has been reported incidentally in females, rar...

Topics

Adult
Aged
Brain
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis
Mutation
Optic Atrophies, Hereditary

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