Article
Association of the 11778 mitochondrial DNA mutation and demyelinating disease.
Neurology - 1 Dec 1993
Flanigan K M, Johns D R
Abstract excerpt
Leber's hereditary optic neuropathy is a maternally inherited disorder most commonly associated with a mitochondrial DNA mutation at nucleotide position 11778. We report four patients, including a man and a black woman, with the 11778 mutation, who have optic neuropathy and clinical or paraclinic...
Topics
- Adult
- DNA, Mitochondrial
- Demyelinating Diseases
- Female
- Humans
- Male
- Mutation
- Optic Atrophies, Hereditary