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Article

Leber's "plus": neurological abnormalities in patients with Leber's hereditary optic neuropathy.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 1995

Nikoskelainen E K, Marttila R J, Huoponen K, Juvonen V, Lamminen T, Sonninen P, Savontaus M L

Abstract excerpt

Previous studies suggest that Leber's hereditary optic neuropathy (LHON) may be a systemic disorder with manifestations in organs other than the optic nerves. To evaluate nervous system involvement 38 men and eight women with LHON were re-examined. The patients were divided into three groups according to mtDNA analysis--namely, patients with the 11778 or with the 3460 mutation and patients without these primary...

Topics

Adult
Brain
Female
Finland
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Mutation
Nervous System Diseases
Optic Atrophies, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7629530
DOI: 10.1136/jnnp.59.2.160
PMCID: PMC485991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7629530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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