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Article

Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase.

Acta crystallographica. Section D, Biological crystallography - 1 Dec 2011

Zarzycki Marek, Kołodziejczyk Robert, Maciaszczyk-Dziubinska Ewa, Wysocki Robert, Jaskolski Mariusz, Dzugaj Andrzej

Abstract excerpt

Human fructose-1,6-bisphosphatase is an allosteric enzyme that is regulated by different ligands. There are only two known isozymes in human tissues: the liver isozyme (the key enzyme of gluconeogenesis), which is regulated by fructose 2,6-bisphosphate, and its muscle counterpart (participating in glycogen synthesis), which is regulated by calcium ions. AMP, which is an allosteric inhibitor of both isozymes,...

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Identifiers

PMID: 22120740
DOI: 10.1107/S090744491104385X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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