Article
LmrCD is a major multidrug resistance transporter in Lactococcus lactis.
Molecular microbiology - 1 Aug 2006
Lubelski Jacek, de Jong Anne, van Merkerk Ronald, Agustiandari Herfita, Kuipers Oscar P, Kok Jan, Driessen Arnold J M
Abstract excerpt
When Lactococcus lactis is challenged with drugs it displays a multidrug resistance (MDR) phenotype. In silico analysis of the genome of L. lactis indicates the presence of at least 40 putative MDR transporters, of which only four, i.e. the ABC transporters LmrA, LmrC and LmrD, and the major facilitator LmrP, have been experimentally associated with the MDR. To understand the molecular basis of the MDR phenotype...
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