Article
Detection by reversed-phase HPLC of trace amounts of the alpha 113His globin chain in a sheep homozygous for a quadruple alpha-globin gene chromosome.
The International journal of biochemistry - 1 Dec 1993
Vestri R, Pieragostini E, Manca L, Masala B
Abstract excerpt
1. In sheep alpha alpha 113His and alpha D alpha alpha 113His globin gene haplotypes, the percentage gene efficiencies, from the 5' to the 3' end, are about 32-18 and 30-14-6, respectively. 2. We previously found that in a alpha alpha alpha alpha homozygote there may be a 1-2% alpha 113His chains, which however were difficult to resolve from alpha 113Leu chains by CMC chromatography. 3. We report here the...
Topics
- Animals
- Chromatography, High Pressure Liquid
- Chromosome Mapping
- Genotype
- Globins
- Haplotypes
- Histidine
- Homozygote
- Sheep