Article
Efficient inhibition of both syncytium-inducing and non-syncytium-inducing wild-type HIV-1 by lamivudine in vivo.
AIDS (London, England) - 9 Jul 1998
van 't Wout A B, Ran L J, Nijhuis M, Tijnagel J M, de Groot T, van Leeuwen R, Boucher C A, Schuitemaker H, Schuurman R
Abstract excerpt
OBJECTIVE: To determine the effect of lamivudine (3TC) on syncytium-inducing (SI) and non-SI (NSI) HIV-1 populations in vivo. DESIGN: Responses in virus load and 3TC resistance in 40 3TC-treated subjects were analysed in relation to the presence or absence of SI HIV-1 variants. METHODS: Peripheral blood samples were collected at regular intervals from 40 HIV-1-infected subjects during 3TC treatment. Virus...
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