Article
A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration - 1 Dec 1995
Skoog I, Vanmechelen E, Andreasson L A, Palmertz B, Davidsson P, Hesse C, Blennow K
Abstract excerpt
Alzheimer's disease (AD) is the most common form of dementia, and is characterized by a degeneration of neurones and their synapses, and a higher number of senile plaques (SP) and neurofibrillary tangles (NFT) compared with that found in non-demented individuals of the same age. NFT are composed of a hyperphosphorylated and ubiquitinated form of tau protein. Previous studies have found that in the cerebrospinal...
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