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Article

De novo design of the hydrophobic core of ubiquitin.

Protein science : a publication of the Protein Society - 1 Jun 1997

Lazar G A, Desjarlais J R, Handel T M

Abstract excerpt

We have previously reported the development and evaluation of a computational program to assist in the design of hydrophobic cores of proteins. In an effort to investigate the role of core packing in protein structure, we have used this program, referred to as Repacking of Cores (ROC), to design several variants of the protein ubiquitin. Nine ubiquitin variants containing from three to eight hydrophobic core...

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Identifiers

PMID: 9194177
DOI: 10.1002/pro.5560060605
PMCID: PMC2143711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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