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Article

Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin.

Microbial pathogenesis - 1 Aug 1996

Lock R A, Zhang Q Y, Berry A M, Paton J C

Abstract excerpt

When 30 clinical isolates of Streptococcus pneumoniae, representing 16 capsular serotypes, were analysed by Western blot for production of the haemolytic toxin pneumolysin (Ply), all strains produced an immunoreactive band of similar intensity. However, six isolates of serotype 8 and two of type 7F expressed Ply whose mobility on SDS-PAGE was anomalously slow. Culture lysates from these strains also had low...

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PMID: 8844651
DOI: 10.1006/mpat.1996.0044

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SDS

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