Article
Inactivation of the streptococcal erythrogenic toxin B gene (speB) in Streptococcus pyogenes.
Infection and immunity - 1 Sept 1993
Chaussee M S, Gerlach D, Yu C E, Ferretti J J
Abstract excerpt
Streptococcal proteinase precursor (SPP) is a zymogen secreted by Streptococcus pyogenes that becomes activated to a cysteine proteinase. SPP has been shown to be immunologically identical to streptococcal erythrogenic toxin B (SPE B), and sequence comparison has shown a high degree of homology between the two proteins. In this study, we have constructed a speB mutant strain of S. pyogenes by insertional...
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