Article
EXPRESSION AND FUNCTION OF HLA‐DQ8 (DQA1*0301/DQB1*0302) GENES IN TRANSGENIC MICE
1 Feb 1996
Abstract excerpt
Transgenic mice expressing HLA-DQA1*0301 and HLA-DQB1*0302 genes (DQ8) were produced. The transgenes were then transferred into mouse (Ab degrees) class II negative mice: the only class II molecules expressed in these animals were therefore coded by the HLA-DQ8 genes. Good expression of HLA-DQ molecules was found. Both CD4+ T cells and DQ8-specific T-cell receptor V beta expressing cells were positively selected...
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