Article
HLA antibody responses in HLA class I transgenic mice.
Immunogenetics - 1 Jan 1990
Tahara T, Yang S Y, Khan R, Abish S, Hämmerling G J, Hämmerling U
Abstract excerpt
In a previous report we described how cross-immunizations of pairs of transgenic mice expressing different HLA class I antigens led to the production of antibodies directed exclusively at polymorphic epitopes. This was ascribed to self-tolerance of HLA that prevents immune responses to monomorphic epitopes and focuses responses on polymorphic ones. In the present report we extend our findings and demonstrate that...
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