HLA antibody responses in HLA class I transgenic mice.

doi:10.1007/BF00211650

Back to search

Article

HLA antibody responses in HLA class I transgenic mice.

Immunogenetics - 1 Jan 1990

Tahara T, Yang S Y, Khan R, Abish S, Hämmerling G J, Hämmerling U

Abstract excerpt

In a previous report we described how cross-immunizations of pairs of transgenic mice expressing different HLA class I antigens led to the production of antibodies directed exclusively at polymorphic epitopes. This was ascribed to self-tolerance of HLA that prevents immune responses to monomorphi...

Topics

Alleles
Animals
Antibodies, Monoclonal
Histocompatibility Antigens Class I
Immunity
Mice
Mice, Transgenic
Polymorphism, Genetic
Transfection

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.