Article
A new immune escape mutant of hepatitis B virus with an Asp to Ala substitution in aa144 of the envelope major protein.
Research in virology - 1 Jan 2000
Ni F, Fang D, Gan R, Li Z, Duan S, Xu Z
Abstract excerpt
A new hepatitis B virus (HBV) mutant with an Asp to Ala substitution in aa144 of the envelope major protein was identified from the blood samples of two persistently infected patients. They were born to HBsAg-positive carrier mothers. The patients had been immunized with HBV vaccine after birth, under a standard schedule of 3 injections at 0, 1 and 6 months, but failed to be protected. The mutant was stable and...
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