Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas.

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Article

Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas.

Journal of lipid research - 1 Jul 1996

Giry C, Giroux L M, Roy M, Davignon J, Minnich A

Abstract excerpt

It is proposed that, in hyperlipidemia, foam cells develop in cutaneous xanthomas from the uptake by the macrophage scavenger receptor (SR) of low density lipoproteins (LDL) that are modified due to increased residence time in plasma. We have observed extensive xanthelasmas and planar xanthomas i...

Topics

Aged
Cholesterol
Esterification
Female
Gene Expression
Humans
Lipoproteins, LDL
Macrophage Colony-Stimulating Factor
Macrophages
Male
Membrane Proteins
Middle Aged
Monocytes
Neck
Nose
Oxidation-Reduction
Pedigree
Phenotype

Source

Open in PubMed

Identifiers

PMID: 8827515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8827515-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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