Article
Monocyte phenotyping and management of lipoprotein X syndrome.
Journal of clinical lipidology - 1 Jan 2000
Lian Zeqin, Saeed Anum, Peng Xueying, Perrard Xiaoyuan Dai, Jia Xiaoming, Hussain Aliza, Ballantyne Christie M, Wu Huaizhu
Abstract excerpt
BACKGROUND: Accumulation of lipoprotein X (LpX) in blood can cause severe hypercholesterolemia and cutaneous xanthomas. Monocytes sensitively sense lipid changes in circulation and contribute to inflammation. However, how monocytes respond to LpX is undefined. OBJECTIVE: We examined the phenotype of monocytes from a patient, who had LpX, severe hypercholesterolemia, and extensive cutaneous xanthomas, and effects...
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