Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transdominant inhibition of Moloney murine leukemia virus proliferation by defective mutants of reverse transcriptase.

Journal of biochemistry - 1 Jun 1996

Shirasawa Y, Sato S, Osawa T, Hirashima A

Abstract excerpt

To investigate the dominant-negative inhibition of Moloney murine leukemia virus (Mo-MuLV) proliferation by polymerization-defective mutants of reverse transcriptase (RT), we constructed several plasmids harboring the Mo-MuLV RT gene in which the YVDD sequence, one of the conserved sequences in RNA-dependent polymerases, was altered, and then transformed mouse NIH3T3 cells and Escherichia coli with the mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to DNA, Complementary
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Plasmids

Share to Protein Binding

Share to Transfection

Source

Identifiers

PMID: 8827439
DOI: 10.1093/oxfordjournals.jbchem.a021349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Transdominant inhibition of Moloney murine leukemia virus proliferation by defective mutants of reverse transcriptase.PMID 8827439Read ↗

Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases.Semantic proximity Read ↗

AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP.Semantic proximity Read ↗

Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.Semantic proximity Read ↗

The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance.Semantic proximity Read ↗

Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses.Semantic proximity Read ↗

Inhibition of HIV/SIV replication by dominant negative Gag mutants.Semantic proximity Read ↗

Host Restriction Factors Blocking Retroviral ReplicationSemantic proximity Read ↗

Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.