Article
Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions.
Chemico-biological interactions - 27 Sept 1996
Bogliolo M, Fronza G, Campomenosi P, Assereto P, Izzotti A, Petrilli G L, Abbondandolo A, De Flora S
Abstract excerpt
In the framework of a project investigating the possible involvement of cancer biomarkers in human atherogenesis, we evaluated the occurrence of K-ras mutations in the DNA extracted from smooth muscle cells of abdominal aorta atherosclerotic lesions. The molecular analysis of the DNA from 32 surgical specimens, using PCR-based denaturing gradient gel electrophoresis (DGGE), did not reveal any variant in K-ras...
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