A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.

doi:10.1212/wnl.50.5.1458

Back to search

Article

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.

Neurology - 1 May 1998

Checkoway H, Franklin G M, Costa-Mallen P, Smith-Weller T, Dilley J, Swanson P D, Costa L G

Abstract excerpt

In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele,...

Topics

Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Genotype
Humans
Male
Middle Aged
Monoamine Oxidase
Parkinson Disease
Polymorphism, Genetic
Risk Factors
Smoking

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.