Article
Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 May 1994
Hotamisligil G S, Girmen A S, Fink J S, Tivol E, Shalish C, Trofatter J, Baenziger J, Diamond S, Markham C, Sullivan J
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disorder caused by loss of dopaminergic neurons in the brainstem. Recent studies suggest that several genes may have a role in determining individual susceptibility to this disease, and the degradative enzyme monoamine oxidase (MAO) has been implicated in the disease process. Wide differences in activity levels for both forms of this enzyme (MAO-A and MAO-B)...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Child
- Child, Preschool
- Gene Frequency
- Genetic Variation
- Haplotypes
- Humans