Article
Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma.
Carcinogenesis - 1 Sept 1996
Hand P A, Inskip A, Gilford J, Alldersea J, Elexpuru-Camiruaga J, Hayes J D, Jones P W, Strange R C, Fryer A A
Abstract excerpt
We describe studies to assess the influence of polymorphism in the human glutathione S-transferase GSTM3 gene on susceptibility to high grade astrocytoma. Immunohistochemical studies using a GSTM3-specific antiserum identified expression of the GSTM3 subunit in astrocytes. The relative levels of expression of GSTM1 and GSTM3 in brain cytosols were determined after resolution of these enzymes using...
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