Article
Microsatellite instability differences between familial and sporadic ovarian cancers.
Carcinogenesis - 1 Sept 1996
Arzimanoglou I I, Lallas T, Osborne M, Barber H, Gilbert F
Abstract excerpt
DNA instability, reflected in altered patterns of short tandem repeat sequences (microsatellites) in dividing cells, has been described in hereditary non-polyposis colon cancer (HNPCC) and in other tumor types. Ovarian cancer (OC), although most often a sporadic cancer, can recur, with HNPCC, as part of the Lynch cancer family syndrome. In an investigation of microsatellite instability (MIN) in 90 OC cases, we...
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