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Article

BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model

1 Jun 2011

Abstract excerpt

PURPOSE: BRAF is frequently activated by gene fusion or point mutation in pilocytic astrocytoma, the most common pediatric brain tumor. We investigated the functional effect of constitutive BRAF activation in normal human neural stem and progenitor cells to determine its role in tumor induction in the brain. EXPERIMENTAL DESIGN: The constitutively active BRAF(V600E) allele was introduced into human neurospheres,...

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PMID: 21636552
DOI: 10.1158/1078-0432.ccr-10-3349

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