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Article

Use of a minimum perturbation approach to predict TIM mutant structures.

Protein engineering - 1 Nov 1995

Joseph-McCarthy D, Petsko G A, Karplus M

Abstract excerpt

A minimum perturbation conformational search approach is used to model the structures of the yeast triosephosphate isomerase (TIM) single mutant in which the catalytic base Glu165 is changed to Asp, and the double mutant in which Glu165 is changed to Asp and Ser96 to Pro. In chicken TIM this double mutant is referred to as a pseudo-revertant because some of the catalytic activity lost due to the first mutation is...

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PMID: 8819976
DOI: 10.1093/protein/8.11.1103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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