Use of a minimum perturbation approach to predict TIM mutant structures.

doi:10.1093/protein/8.11.1103

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Article

Use of a minimum perturbation approach to predict TIM mutant structures.

Protein engineering - 1 Nov 1995

Joseph-McCarthy D, Petsko G A, Karplus M

Abstract excerpt

A minimum perturbation conformational search approach is used to model the structures of the yeast triosephosphate isomerase (TIM) single mutant in which the catalytic base Glu165 is changed to Asp, and the double mutant in which Glu165 is changed to Asp and Ser96 to Pro. In chicken TIM this doub...

Topics

Amino Acid Sequence
Computer Simulation
Models, Molecular
Molecular Sequence Data
Mutation
Software
Thermodynamics
Triose-Phosphate Isomerase
Yeasts

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