[Molecular and clinical abnormalities of apolipoprotein A-I].

Abstract excerpt

Several epidemiological and clinical studies have shown an inverse correlation between low plasma concentration of high density lipoprotein (HDL) cholesterol as well as its major protein component, apolipoprotein A-I (apo A-I), and the risk of coronary artery disease. Apo A-I plays an important role in a reverse cholesterol transport. In this model, HDL mediates the cholesterol flux from peripheral cells to the...

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