Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.

Nucleic acids research - 1 Feb 2002

Selzer Rebecca R, Nyaga Simon, Tuo Jingsheng, May Alfred, Muftuoglu Meltem, Christiansen Mette, Citterio Elisabetta, Brosh Robert M, Bohr Vilhelm A

Abstract excerpt

Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, developmental abnormalities and premature aging. The cellular and molecular phenotypes of CS include increased sensitivity to oxidative and UV-induced DNA lesions. The CSB protein is thought to play a pivotal role in transcription-coupled repair and CS-B cells are defective in the repair of the transcribed strand of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Extracts
Share to Cockayne Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine

Share to DNA Repair Enzymes

Share to Guanine

Share to Poly-ADP-Ribose Binding Proteins

Share to Radiation Tolerance

Share to Thymine

Source

Open in PubMed Open full text

Identifiers

PMID: 11809892
DOI: 10.1093/nar/30.3.782
PMCID: PMC100288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.PMID 11809892Read ↗

Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene.Semantic proximity Read ↗

Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product.Semantic proximity Read ↗

Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal.Semantic proximity Read ↗

Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.Semantic proximity Read ↗

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and agingSemantic proximity Read ↗

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8‐hydroxyguanine and 8‐hydroxyadenine resulting from oxidative stressSemantic proximity Read ↗

Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome.Semantic proximity Read ↗

Cockayne syndrome group B protein regulates DNA double‐strand break repair and checkpoint activationSemantic proximity Read ↗

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.Semantic proximity Read ↗

Cockayne syndrome group B protein has novel strand annealing and exchange activitiesSemantic proximity Read ↗

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.Semantic proximity Read ↗

The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.