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Decreased Expression of Retinoid Receptors in Melanoma: Entailment in Tumorigenesis and Prognosis

15 Aug 2007

Abstract excerpt

PURPOSE: Retinoids inhibit proliferation and induce differentiation in melanoma cells. Retinoic acid receptors (RAR) and retinoid X receptors (RXR) mediate the various modulatory effects of retinoids in cells. We have studied the in situ expression of each RAR and RXR protein (alpha, beta, gamma) in a large series of melanocytic lesions and correlated the expression with clinicopathologic features and prognosis...

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PMID: 17699860
DOI: 10.1158/1078-0432.ccr-06-3026

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