Article
Flexibility in the second half-site sequence recognised by the c-Myb R2 domain--in vitro and in vivo analysis.
Oncogene - 5 Sept 1996
Ording E, Bergholtz S, Brendeford E M, Jamin N, Gabrielsen O S
Abstract excerpt
The oncoprotein c-Myb is a transcription factor that recognises its specific target sequences through two subdomains. The R3-domain binds the first half-site, YAAC, and plays a dominant role in sequence recognition, while the homologous R2-domain interacts with a more loosely defined sequence in the second half-site. The difficulty in precisely defining a preferred second half-site sequence might reflect the...
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