Article
Flexibility in the second half-site sequence recognised by the c-Myb R2 domain--in vitro and in vivo analysis.
Oncogene - 5 Sept 1996
Ording E, Bergholtz S, Brendeford E M, Jamin N, Gabrielsen O S
Abstract excerpt
The oncoprotein c-Myb is a transcription factor that recognises its specific target sequences through two subdomains. The R3-domain binds the first half-site, YAAC, and plays a dominant role in sequence recognition, while the homologous R2-domain interacts with a more loosely defined sequence in...
Topics
- Binding Sites
- DNA
- DNA-Binding Proteins
- Electrophoresis
- Genes, Reporter
- Guanosine
- Methylation
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Protein Conformation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myb
- Trans-Activators
- Transcriptional Activation
- Yeasts