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Article

Reduction of a conserved Cys is essential for Myb DNA-binding.

Nucleic acids research - 11 May 1992

Guehmann S, Vorbrueggen G, Kalkbrenner F, Moelling K

Abstract excerpt

The human c-Myb gene product is a regulator of transcription with intrinsic DNA-binding activity located in two of three aminoterminal repeats R2R3. Three purified recombinant c-Myb proteins, a 42 kD protein corresponding to the amino-terminal half (HM42), and two proteins representing R2R3 or R1R2R3 (HMR23 and HMR123) have been analyzed either as purified proteins or present in bacterial extracts in gelshift...

Topics

Alkylation
Base Sequence
Cysteine
DNA
Diamide
Electrophoresis, Polyacrylamide Gel
Gene Expression
Humans
Molecular Sequence Data
Mutation
Oxidation-Reduction
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-myb

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Identifiers

PMID: 1594446
DOI: 10.1093/nar/20.9.2279
PMCID: PMC312342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1594446-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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