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Nuclear Localization of Japanese Encephalitis Virus Core Protein Enhances Viral Replication

24 Feb 2005

Abstract excerpt

Japanese encephalitis virus (JEV) core protein was detected in both the nucleoli and cytoplasm of mammalian and insect cell lines infected with JEV or transfected with the expression plasmid of the core protein. Mutation analysis revealed that Gly(42) and Pro(43) in the core protein are essential for the nuclear and nucleolar localization. A mutant M4243 virus in which both Gly(42) and Pro(43) were replaced by...

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PMID: 15731239
DOI: 10.1128/jvi.79.6.3448-3458.2005

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