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Article

'Mutational SURF': a strategy for improving lead compounds identified from combinatorial libraries.

Bioorganic & medicinal chemistry - 1 May 1996

Freier S M, Konings D A, Wyatt J R, Ecker D J

Abstract excerpt

Synthesis and testing of mixtures of compounds in a combinatorial library offers the potential of much greater throughput than the 'one compound, one well' approach. When mixtures of compounds are screened, however, pooling and deconvolution strategies must be employed to identify the most active compound in the library. The possibility exists that the most active compound will not be identified. We have...

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PMID: 8804538
DOI: 10.1016/0968-0896(96)00068-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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