Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells.

doi:10.1016/0014-5793(96)00862-9

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Article

Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells.

FEBS letters - 9 Sept 1996

Fujii Y, Otake K, Tashiro M, Adachi A

Abstract excerpt

We have previously shown that the carboxyl-terminal region of human immunodeficiency virus type 1 (HIV-1) Nef antigen present on the outer surface of virus-infected cells has affinity for uninfected T cells. Here, the in vitro cytotoxic potential of HIV-1 Nef on the T cell surface against CD4+ T...

Topics

CD4-Positive T-Lymphocytes
Cell Line
Cell Membrane
Cytotoxicity Tests, Immunologic
Cytotoxins
Gene Products, nef
HIV-1
Humans
Mutation
Structure-Activity Relationship
Transfection
nef Gene Products, Human Immunodeficiency Virus

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