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Article

Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells.

FEBS letters - 9 Sept 1996

Fujii Y, Otake K, Tashiro M, Adachi A

Abstract excerpt

We have previously shown that the carboxyl-terminal region of human immunodeficiency virus type 1 (HIV-1) Nef antigen present on the outer surface of virus-infected cells has affinity for uninfected T cells. Here, the in vitro cytotoxic potential of HIV-1 Nef on the T cell surface against CD4+ T cells was investigated in detail. Human T cells expressing Nef on the cell surface by transfection with non-infectious...

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Identifiers

PMID: 8804435
DOI: 10.1016/0014-5793(96)00862-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells.PMID 8804435Read ↗

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Downregulation of cell surface CD4 by nefSemantic proximity Read ↗

The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.Semantic proximity Read ↗

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.Semantic proximity Read ↗

Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.Semantic proximity Read ↗

Simian immunodeficiency viruses with defective nef genes show increased susceptibility to the noncytotoxic antiviral activity of CD8+ lymphocytes.Semantic proximity Read ↗

Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic DomainSemantic proximity Read ↗

HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants.Semantic proximity Read ↗

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanismsSemantic proximity Read ↗

Characterization of human CD4+, HIV-SF2 Nef-specific T-cell clones for antigen-processing and presentation requirements and for cytotoxic activity.Semantic proximity Read ↗

Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.Semantic proximity Read ↗

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