Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies.

doi:10.1016/0264-410x(93)90359-6

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Article

Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies.

Vaccine - 1 Jan 1993

Fujii Y, Ito M, Ikuta K

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) can lead to a profound CD4+ T-cell deficiency. To examine the functional role of HIV-1 Nef protein on the marked loss of CD4+ cells, Nef protein was expressed in and purified from Escherichia coli as a fusion protein with T7 phage gene10 product (Nef-gene10). When peripheral blood mononuclear cells (PBMC) from healthy donors were cultivated in the presence of Nef-gene10...

Topics

Animals
Antibodies
Bacteriophage T7
Base Sequence
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes
Cell Division
Cells, Cultured
Escherichia coli
Gene Expression
Gene Products, nef

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, nef

HIV-1

Humans

Interleukin-2

Ligands

Lymphocyte Activation

Major Histocompatibility Complex

Source

Open in PubMed

Identifiers

PMID: 8102828
DOI: 10.1016/0264-410x(93)90359-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8102828-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies.PMID 8102828Read ↗

Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells.Semantic proximity Read ↗

Intra-host competition between nef-defective escape mutants and wild-type human immunodeficiency virus type 1.Semantic proximity Read ↗

T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects.Semantic proximity Read ↗

Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic DomainSemantic proximity Read ↗

cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.Semantic proximity Read ↗

Towards a consensus for a role of Nef in both viral replication and immunomodulation?Semantic proximity Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 + T-Cell Depletion in Human Lymphoid Tissue Ex VivoSemantic proximity Read ↗

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