Article
CSF-1 deficiency in mice results in abnormal brain development.
Development (Cambridge, England) - 1 Sept 1996
Michaelson M D, Bieri P L, Mehler M F, Xu H, Arezzo J C, Pollard J W, Kessler J A
Abstract excerpt
Colony stimulating factor-1 (CSF-1) was initially identified as a growth factor for mononuclear phagocytes. This study examines the role of CSF-1 in the development of the central nervous system (CNS). CSF-1 treatment of neurons cultured from embryonic brain promoted survival and process outgrowt...
Topics
- Animals
- Base Sequence
- Bicuculline
- Brain
- Cells, Cultured
- Electrophysiology
- Evoked Potentials
- GABA Antagonists
- Genes, fms
- Macrophage Colony-Stimulating Factor
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Neurons
- Osteopetrosis
- RNA Splicing
- RNA, Messenger