Article
No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma.
Human genetics - 1 Mar 1996
Hofstra R M, Cheng N C, Hansen C, Stulp R P, Stelwagen T, Clausen N, Tommerup N, Caron H, Westerveld A, Versteeg R, Buys C H
Abstract excerpt
Neuroblastoma occasionally occurs in diseases associated with abnormal neurocrest differentiation, e.g. Hirschsprung disease. Expression studies in developing mice suggest that the proto-oncogene RET plays a role in neurocrest differentiation. In humans expression of RET is limited to certain tumor types, including neuroblastoma, that derive from migrating neural crest cells. Mutations of RET are found associated...
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