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Article

The neutralizing epitope ELDKWA on HIV-1 gp41: genetic variability and antigenicity.

Immunology letters - 15 Oct 2005

Dong Xiao-Nan, Wu Yi, Chen Ying-Hua

Abstract excerpt

Viral evasion through mutations of neutralizing epitopes is a major challenge to AIDS vaccine development and clinical therapy. In this study, we analyzed the genetic variability of principal neutralizing epitope ELDKWA among 5393 HIV isolates in the HIV sequence database (). It has been found that six out of seven frequent variants were able to cause the invalidation of famous neutralizing MAb 2F5. Moreover,...

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Source

Identifiers

PMID: 15951025
DOI: 10.1016/j.imlet.2005.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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