Article
MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.
Tissue antigens - 1 Apr 1996
Just J J, Casabona J, Bertrán J, Montané C, Fortuny C, Rodrigo C, Mur A, Bosque M, Jovane L, King M C
Abstract excerpt
Children with perinatally-acquired HIV-1 infection were studied to determine if major histocompatibility complex (MHC) genes are involved in progression to pediatric AIDS. Molecular genetic techniques were used to genotype loci in the class II region (DRB1, DQA1, DQB1, DPA1, DPB1, LMP2 and LMP7). HIV-infected children were classified by clinical manifestations and degree of immunosuppression using age-specific...
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