MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.

doi:10.1111/j.1399-0039.1996.tb02559.x

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Article

MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain.

Tissue antigens - 1 Apr 1996

Just J J, Casabona J, Bertrán J, Montané C, Fortuny C, Rodrigo C, Mur A, Bosque M, Jovane L, King M C

Abstract excerpt

Children with perinatally-acquired HIV-1 infection were studied to determine if major histocompatibility complex (MHC) genes are involved in progression to pediatric AIDS. Molecular genetic techniques were used to genotype loci in the class II region (DRB1, DQA1, DQB1, DPA1, DPB1, LMP2 and LMP7). HIV-infected children were classified by clinical manifestations and degree of immunosuppression using age-specific...

Topics

Alleles
CD4 Antigens
HIV Infections
HLA-DQ Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Immune Tolerance
Infant
Infant, Newborn
Polymerase Chain Reaction
Spain

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Identifiers

PMID: 8773321
DOI: 10.1111/j.1399-0039.1996.tb02559.x

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