Article
An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels.
Thrombosis and haemostasis - 1 Dec 1995
Hennis B C, Boomsma D I, van Boheemen P A, Engesser L, Kievit P, Dooijewaard G, Kluft C
Abstract excerpt
A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an...
Topics
- Alleles
- Amino Acids
- Analysis of Variance
- Blood Proteins
- Case-Control Studies
- Chromosome Mapping
- Glycoproteins
- Humans
- Likelihood Functions
- Molecular Weight
- Pedigree
- Phenotype
- Polymorphism, Genetic
- Proteins
- Histidine-Rich Glycoprotein