Article
An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels.
Thrombosis and haemostasis - 1 Dec 1995
Hennis B C, Boomsma D I, van Boheemen P A, Engesser L, Kievit P, Dooijewaard G, Kluft C
Abstract excerpt
A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%. These results are remarkably similar to the...
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